Epigenesis

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Atypical epigenesis.

It is becoming increasingly clear that little in development is predetermined or permanently fixed. Rather, gene expression is activity dependent, and epigenesis is probabilistic. So, the study of genetic disorders needs to change from the still widely held view that developmental disorders can be accounted for in terms of intact versus impaired modules, to one which takes serious account of th...

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Probabilistic epigenesis.

The notion that phenotypic traits, including behavior, can be predetermined has slowly given way in biology and psychology over the last two decades. This shift in thinking is due in large part to the growing evidence for the fundamental role of developmental processes in the generation of the stability and variations in phenotype that researchers in developmental and evolutionary sciences seek...

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Neural correlates of epigenesis.

The effect of life stress on depression is moderated by a repeat length variation in the transcriptional control region of the serotonin transporter gene, which renders carriers of the short variant vulnerable for depression. We investigated the underlying neural mechanisms of these epigenetic processes in individuals with no history of psychopathology by using multimodal magnetic resonance-bas...

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Epigenesis of Language

Studies employing event-related brain potentials (ERPs) and functional magnetic resonance imaging (fMRI) were designed to study the effects of different types of language experience on the development and organization of neural systems important in language processing. Comparisons of cerebral organization in normally hearing, monolingual English speakers with that observed in hearing and deaf l...

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From Epigenesis to Epigenetics

One continuous thread in this volume is the name of Conrad H. Waddington (1905–1975), the developmental biologist known as the inventor of the term epigenetics. After some biographical notes on his life, this article explores the meaning of the Waddingtonian equation and the context wherein it was developed. This equation holds that epigenesis + genetics = epigenetics, and refers in retrospect ...

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ژورنال

عنوان ژورنال: Nature

سال: 1894

ISSN: 0028-0836,1476-4687

DOI: 10.1038/050242a0